Piperidine → HCID 2804025, compound

HRID 6793Notes

Reaction equation

HRID 6793 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([C:13]#[C:14][CH2:15]Br)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([C:13]#[C:14][CH2:15][N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1

Participants

5

Reactant 3

HCID 8082PiperidineHCID 11430Potassium CarbonateHCID 2779977HCID 2779977, compound

Product 1

HCID 2804025HCID 2804025, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 1-(3,5-bistrifluoromethylphenyl)-3-bromoprop-1-yne (2.53 g), piperidine (5 ml) and anhydrous potassium carbonate (5 g) in dry acetone (50 ml) was heated at reflux with stirring for 18 h. Removal of the solvent under reduced pressure and distillation of the residue under reduced pressure gave 2.26 g of an oil of boiling point 95° C./0.025 mm Hg.

Workup

  1. temperaturewas heated
  2. temperatureat reflux
  3. customRemoval of the solvent
  4. distillationunder reduced pressure and distillation of the residue under reduced pressure

Sources & evidence

ORD record
ord-02f0b0daf7f34f13804f67028ba672a7
Source dataset
uspto-grants-2006_08
Patent number
US07084158B2

Reaction notes

Loading…