Hydrochloric Acid → 1-[3-(3,5-Bistrifluoromethylphenyl)-2-propynyl]piperidine hydrochloride

HRID 6794Notes

Reaction equation

HRID 6794 reaction equation
[ClH:1].[F:2][C:3]([F:24])([F:23])[C:4]1[CH:5]=[C:6]([C:14]#[C:15][CH2:16][N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1>C(OCC)C>[ClH:1].[F:13][C:10]([F:11])([F:12])[C:8]1[CH:7]=[C:6]([C:14]#[C:15][CH2:16][N:17]2[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2)[CH:5]=[C:4]([C:3]([F:23])([F:24])[F:2])[CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 2804025HCID 2804025, compound

Product 1

HCID 28040241-[3-(3,5-Bistrifluoromethylphenyl)-2-propynyl]piperidine hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

An excess of dry HCl gas was passed through a solution of 1-(3,5-bistrifluoromethylphenyl)-3-piperidinoprop-1-yne (2.26 g) in dry diethyl ether (200 ml). Filtration, washing (diethyl ether) and drying of the resulting white precipitate gave 2.16 g of a fine white powder of melting point 214.5° C.

Workup

  1. filtrationFiltration
  2. washwashing (diethyl ether)
  3. customdrying of the resulting white precipitate

Sources & evidence

ORD record
ord-ed06c24c01b04411accf6dff0f2cccde
Source dataset
uspto-grants-2006_08
Patent number
US07084158B2

Reaction notes

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