Acetone → 1-Bromo-5-ethoxy-2,4-difluorobenzene

HRID 680972Notes

Reaction equation

HRID 680972 reaction equation
[Br:1][c:2]1[c:3]([F:10])[cH:4][c:5]([F:9])[c:6]([OH:8])[cH:7]1.[CH3:20][CH2:21][O:22][C:23]([CH3:24])=[O:25].[CH3:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31].[CH3:32][C:33](=[O:34])[CH3:35].[CH3:36][CH2:37][O:38][CH2:39][CH3:40].[I:17][CH2:18][CH3:19].[K+:11].[K+:12].[O-:13][C:14]([O-:15])=[O:16]>>[Br:1][c:2]1[c:3]([F:10])[cH:4][c:5]([F:9])[c:6]([O:8][CH2:18][CH3:19])[cH:7]1

Participants

9

Reactant 8

HCID 180AcetoneHCID 813Potassium Cation2×HCID 3283Diethyl EtherHCID 6340IodoethaneHCID 8058HexaneHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 98343005-Bromo-2,4-difluorophenol

Product 1

HCID 579426611-Bromo-5-ethoxy-2,4-difluorobenzene

Sources & evidence

ORD record
ord-5de31a3d31d74ff5821bc1c5b4e7f214
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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