4-Hydroxybenzaldehyde → Carbonic acid, ethyl 4-formylphenyl ester

To a 250 mL dry round bottom flask were added 4-hydroxybenzaldehyde (6.11 g, 50.0 mmol), anhydrous CH2Cl2 (150 mL). The solution was cooled in an ice-water bath, then pyridine (4.86 mL, 60.0 mmol) was added. To the resulting solution, ethyl chloroformate (4.78 mL, 50.0 mmol) was added slowly under stirring and N2. The mixture was stirred and warmed to room temperature, then stirred at room temperature overnight. To the reaction mixture, water (100 mL) was added and the CH2Cl2 layer was separated. The aqueous layer was extracted continually with CH2Cl2 (100 mL×2). The combined CH2Cl2 solution was dried over Na2SO4. After removal of the solvent, the residue was purified with a silica gel chromatography (heptane/ethyl acetate, gradient eluting) to give ethyl 4-formylphenyl carbonate (8.92 g) as colorless oil. Yield: 92%. 1H NMR (CDCl3, 300 MHz): δ=10.07 (s, 1H), 8.00 (d, J=8.7 Hz, 2H), 7.45 (d, J=8.7 Hz, 2H), 4.42 (q, J=7.2 Hz, 2H), 1.47 (t, J=7.2 Hz, 3H). 13C NMR (CDCl3, 75.5 MHz): δ=191.0, 155.7, 152.9, 134.2, 131.4, 121.9, 65.4, 14.3.

1. customTo a 250 mL dry round bottom flask
2. temperatureThe solution was cooled in an ice-water bath
3. stirringThe mixture was stirred
4. stirringstirred at room temperature overnight
5. customthe CH2Cl2 layer was separated
6. extractionThe aqueous layer was extracted continually with CH2Cl2 (100 mL×2)
7. dry with materialThe combined CH2Cl2 solution was dried over Na2SO4
8. customAfter removal of the solvent
9. customthe residue was purified with a silica gel chromatography (heptane/ethyl acetate, gradient eluting)

ORD record

ord-5af65915f8584af7a71d08060c9d236a

Source dataset

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08822435B2