反应详情

温度

25 °C

To a solution of the product of step 3 (28 g, 0.0683 moles) in THF (140 ml), a solution of lithium hydroxide (4.3 g, 0.1024 moles) in water (140 ml) was added and the reaction mixture was stirred at 25° C. for 3 hours. The solvents were evaporated under reduced pressure. The residue was dissolved in water, acidified with 1N HCl and extracted with ethyl acetate. The combined ethyl acetate extract was washed with water & brine, dried over sodium sulphate and evapourated under reduced pressure to yield 23 gm (88%) of product as solid.

1. customThe solvents were evaporated under reduced pressure
2. dissolutionThe residue was dissolved in water
3. extractionextracted with ethyl acetate
4. extractionThe combined ethyl acetate extract
5. washwas washed with water & brine
6. dry with materialdried over sodium sulphate