反应详情

To a solution of the product of step 1 (1.1 gm, 5.3 mmoles) in a mixture of THF (12 ml), methanol (4 ml) and water (4 ml), lithium hydroxide (444 mg, 10.6 mmoles) was added and the reaction mixture was stirred at ambient temperature for 4 hours. The solvents were evaporated under reduced pressure. The residue was dissolved in water, acidified with 1N HCl and evaporated in vacuum. The residue was diluted with ethyl acetate, stirred for 30 min and filtered. The filtrate was concentrated in vacuum to yield 1.0 gm (98%) of title product as off white solid.

1. additionwas added
2. customThe solvents were evaporated under reduced pressure
3. dissolutionThe residue was dissolved in water
4. customevaporated in vacuum
5. additionThe residue was diluted with ethyl acetate
6. stirringstirred for 30 min
7. filtrationfiltered
8. concentrationThe filtrate was concentrated in vacuum