HRID68354

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6228

N,N-Dimethylformamide

C3H7NO

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

HCID2723939

1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

C8H18ClN3

结构：O=C(O)[C@H]1CC[C@@H]2CN1C(=O)N2OCc1ccccc1

HCID68761009

未命名化合物

HCID71283950

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC[C@@H](C(=O)NNC(=O)[C@H]2CC[C@@H]3CN2C(=O)N3OCc2ccccc2)C1

HCID86719959

未命名化合物

收率 41%

PROCEDURE

实验过程

By using the procedure described in Step-1 of Example-1 above, and by using trans-6-benzyloxy-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carboxylic acid (25 gm, 0.084 mol), N,N-dimethyl formamide (625 ml), EDC hydrochloride (24 gm, 0.126 mol), HOBt (16.96 gm, 0.126 mol), (R)—N-tert-butoxycarbonyl-piperidin-3-carboxylic acid hydrazide (21.40 gm, 0.088 mol) to provide the title compound in 17.0 gm quantity, 41% yield as a white solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-04e8d6daf29743288646af29402fa838
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08822450B2
来源说明: uspto-grants-2014_09

反应 SMILES

[CH2:1]([O:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@@H:13]2[C:18]([OH:20])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CCN=C=NCCCN(C)C.Cl.[CH:33]1[CH:34]=[CH:35][C:36]2N(O)[N:40]=[N:39][C:37]=2C=1.[C:43]([O:47][C:48]([N:50]([C:52]([C@@H]1CCCNC1)=O)N)=[O:49])([CH3:46])([CH3:45])[CH3:44].CN(C)C=[O:63]>>[C:43]([O:47][C:48]([N:50]1[CH2:33][CH2:34][CH2:35][C@@H:36]([C:37]([NH:39][NH:40][C:18]([C@H:13]2[CH2:12][CH2:11][C@@H:10]3[CH2:17][N:14]2[C:15](=[O:16])[N:9]3[O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[O:20])=[O:63])[CH2:52]1)=[O:49])([CH3:46])([CH3:45])[CH3:44]