Pyridine → N-[5-Chloro-4-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]pyridin-2-yl]-1-pyridin-4-ylmethanesulfonamide

HRID 683936Notes

Reaction equation

HRID 683936 reaction equation
[CH2:1]([Cl:2])[Cl:3].[CH3:56][CH2:57][O:58][C:59](=[O:60])[CH3:61].[Cl:4][c:5]1[c:6]([CH:12]([c:13]2[c:14]([F:20])[cH:15][cH:16][c:17]([F:19])[cH:18]2)[S:21](=[O:22])(=[O:23])[c:24]2[cH:25][cH:26][c:27]([Cl:30])[cH:28][cH:29]2)[cH:7][c:8]([NH2:11])[n:9][cH:10]1.[S:37]([OH:38])([C:39]([F:40])([F:41])[F:42])(=[O:43])=[O:44].[cH:31]1[cH:32][cH:33][n:34][cH:35][cH:36]1.[n:45]1[cH:46][cH:47][c:48]([CH2:51][S:52](=[O:53])(=[O:54])[Cl:55])[cH:49][cH:50]1>>[Cl:4][c:5]1[c:6]([CH:12]([c:13]2[c:14]([F:20])[cH:15][cH:16][c:17]([F:19])[cH:18]2)[S:21](=[O:22])(=[O:23])[c:24]2[cH:25][cH:26][c:27]([Cl:30])[cH:28][cH:29]2)[cH:7][c:8]([NH:11][S:52]([CH2:51][c:48]2[cH:47][cH:46][n:45][cH:50][cH:49]2)(=[O:53])=[O:54])[n:9][cH:10]1

Participants

7

Reactant 6

HCID 1049PyridineHCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 62406Trifluoromethanesulfonic acidHCID 3789553Pyridin-4-ylmethanesulfonyl ChlorideHCID 23114671[5-Chloro-4-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]pyridin-2-yl]amine

Product 1

HCID 23114768N-[5-Chloro-4-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]pyridin-2-yl]-1-pyridin-4-ylmethanesulfonamide

Sources & evidence

ORD record
ord-beb3c5d528144385a3fd9f1b36fe113c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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