反应详情

温度

60 °C

18.6 mL triethylamine and piperazine-1-carboxylic acid tert-butyl ester were added to 9.7 g 4-chloro-6-methoxy-pyrimidine in 50 mL DMF. The reaction was stirred over night at 60° C. The reaction was cooled and the precipitate was filtered. The filtrate was evaporated. The residue was dissolved in DCM, extracted with water and washed with sodium chloride solution. The solvent was evaporated and the residue was crystallized with a mixture of petrolether and diethylether (8:2) to yield 8.7 g of the desired compound.

1. temperatureThe reaction was cooled
2. filtrationthe precipitate was filtered
3. customThe filtrate was evaporated
4. dissolutionThe residue was dissolved in DCM
5. extractionextracted with water
6. washwashed with sodium chloride solution
7. customThe solvent was evaporated
8. customthe residue was crystallized with a mixture of petrolether and diethylether (8:2)