Potassium Cation → Ethyl 5-trifluoromethyl-6-methoxybenzo[b]thiophene-3-carboxylate

HRID 685850Notes

Reaction equation

HRID 685850 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([s:6][cH:7][c:8]2[C:9](=[O:10])[O:11][CH2:12][CH3:13])[cH:14][c:15]1[O:16][CH3:17].[CH3:26][N:27]([CH3:28])[CH:29]=[O:30].[CH3:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1.[Cu:38][I:39].[F:18][C:19]([C:20]([O-:21])=[O:22])([F:23])[F:24].[K+:25]>>[c:2]1([C:19]([F:18])([F:23])[F:24])[cH:3][c:4]2[c:5]([s:6][cH:7][c:8]2[C:9](=[O:10])[O:11][CH2:12][CH3:13])[cH:14][c:15]1[O:16][CH3:17]

Participants

7

Reactant 6

HCID 813Potassium CationHCID 1140TolueneHCID 6228DimethylformamideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 84468TrifluoroacetateHCID 53817228Ethyl 5-bromo-6-methoxybenzo[b]thiophene-3-carboxylate

Product 1

HCID 53925736Ethyl 5-trifluoromethyl-6-methoxybenzo[b]thiophene-3-carboxylate

Sources & evidence

ORD record
ord-fbf396a2fa1c41a9a07afc664f0a644d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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