反应详情

To a solution of the compound 24 (3.58 g) and triethylamine (2.76 mL) in ethyl acetate (50 mL), methanesulfonyl chloride (0.78 mL) was slowly added under ice cooling. The reaction mixture was stirred under ice cooling for 2 hours. The reaction mixture was diluted with ethyl acetate (100 mL). The diluted solution was washed in turn with water and saturated brine, dried over anhydrous magnesium sulfate and then concentrated. The residue was purified by silica gel chromatography (ethyl acetate:methanol=1:0→10:1) to obtain the title compound (3.70 g) having the following physical properties.

1. washThe diluted solution was washed in turn with water and saturated brine
2. dry with materialdried over anhydrous magnesium sulfate
3. concentrationconcentrated
4. customThe residue was purified by silica gel chromatography (ethyl acetate:methanol=1:0→10:1)