Hydrochloric Acid → 3-Methoxy-1-phenyl-6-(3-piperazin-1-ylazetidin-1-yl)indazole;hydrochloride

HRID 68707Notes

Reaction equation

HRID 68707 reaction equation
Br[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([O:17][CH3:18])=[N:7][N:8]2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.C(OC([N:26]1[CH2:31][CH2:30][N:29]([CH:32]2[CH2:35][NH:34][CH2:33]2)[CH2:28][CH2:27]1)=O)(C)(C)C.[ClH:36]>>[ClH:36].[CH3:18][O:17][C:6]1[C:5]2[C:9](=[CH:10][C:2]([N:34]3[CH2:35][CH:32]([N:29]4[CH2:30][CH2:31][NH:26][CH2:27][CH2:28]4)[CH2:33]3)=[CH:3][CH:4]=2)[N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 21183794tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylateHCID 674471756-Bromo-3-methoxy-1-phenyl-1H-indazole

Product 1

HCID 674496363-Methoxy-1-phenyl-6-(3-piperazin-1-ylazetidin-1-yl)indazole;hydrochloride

Procedure

The title compound was prepared according to the procedure as described in Example 57 reacting 6-bromo-3-methoxy-1-phenyl-1H-indazole and 4-azetidin-3-yl-piperazine-1-carboxylic acid tert-butyl ester, followed by de-protection with HCl.

Sources & evidence

ORD record
ord-864a5cb0c3de48519624a71efca87960
Source dataset
uspto-grants-2014_09
Patent number
US08822447B2

Reaction notes

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