Hydrochloric Acid → 6-(4-(Azetidin-3-yl)piperazin-1-yl)-3-methoxy-1-phenyl-1H-indazole hydrochloride

HRID 68708Notes

Reaction equation

HRID 68708 reaction equation
Br[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([O:17][CH3:18])=[N:7][N:8]2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.C(OC([N:26]1[CH2:29][CH:28]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[CH2:27]1)=O)(C)(C)C.[ClH:36]>>[ClH:36].[NH:26]1[CH2:29][CH:28]([N:30]2[CH2:35][CH2:34][N:33]([C:2]3[CH:10]=[C:9]4[C:5]([C:6]([O:17][CH3:18])=[N:7][N:8]4[C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)=[CH:4][CH:3]=3)[CH2:32][CH2:31]2)[CH2:27]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 19360775tert-Butyl 3-(piperazin-1-yl)azetidine-1-carboxylateHCID 674471756-Bromo-3-methoxy-1-phenyl-1H-indazole

Product 1

HCID 674487166-(4-(Azetidin-3-yl)piperazin-1-yl)-3-methoxy-1-phenyl-1H-indazole hydrochloride

Procedure

The title compound was prepared according to the procedure as described in Example 57 reacting 6-bromo-3-methoxy-1-phenyl-1H-indazole and 3-piperazin-1-yl-azetidine-1-carboxylic acid tert-butyl ester, followed by de-protection with HCl.

Sources & evidence

ORD record
ord-4d8e62c0be8a4dbea223a33ef1c3fc3d
Source dataset
uspto-grants-2014_09
Patent number
US08822447B2

Reaction notes

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