Hydrochloric Acid → 3-Methoxy-1-phenyl-6-(4-(pyrrolidin-3-yl)piperazin-1-yl)-1H-indazole hydrochloride

HRID 68709Notes

Reaction equation

HRID 68709 reaction equation
Br[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([O:17][CH3:18])=[N:7][N:8]2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.C(OC([N:26]1[CH2:30][CH2:29][CH:28]([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH2:27]1)=O)(C)(C)C.[ClH:37]>>[ClH:37].[CH3:18][O:17][C:6]1[C:5]2[C:9](=[CH:10][C:2]([N:34]3[CH2:33][CH2:32][N:31]([CH:28]4[CH2:29][CH2:30][NH:26][CH2:27]4)[CH2:36][CH2:35]3)=[CH:3][CH:4]=2)[N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 53216205Tert-butyl 3-(piperazin-1-yl)pyrrolidine-1-carboxylateHCID 674471756-Bromo-3-methoxy-1-phenyl-1H-indazole

Product 1

HCID 674472993-Methoxy-1-phenyl-6-(4-(pyrrolidin-3-yl)piperazin-1-yl)-1H-indazole hydrochloride

Procedure

The title compound was prepared according to the procedure as described in Example 57 reacting 6-bromo-3-methoxy-1-phenyl-1H-indazole and 3-piperazin-1-yl-pyrrolidine-1-carboxylic acid tert-butyl ester, followed by de-protection with HCl.

Sources & evidence

ORD record
ord-b7414d30f3714c1bb62762d004a63e9e
Source dataset
uspto-grants-2014_09
Patent number
US08822447B2

Reaction notes

Loading…