Hydrochloric Acid → 3-Methoxy-1-phenyl-6-(4-(pyridin-4-yl)piperazin-1-yl)-1H-indazole hydrochloride

HRID 68711Notes

Reaction equation

HRID 68711 reaction equation
Br[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([O:17][CH3:18])=[N:7][N:8]2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[N:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:21][CH:20]=1.[ClH:31]>>[ClH:31].[CH3:18][O:17][C:6]1[C:5]2[C:9](=[CH:10][C:2]([N:28]3[CH2:29][CH2:30][N:25]([C:22]4[CH:23]=[CH:24][N:19]=[CH:20][CH:21]=4)[CH2:26][CH2:27]3)=[CH:3][CH:4]=2)[N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 705171-(4-Pyridyl)piperazineHCID 674471756-Bromo-3-methoxy-1-phenyl-1H-indazole

Product 1

HCID 674497913-Methoxy-1-phenyl-6-(4-(pyridin-4-yl)piperazin-1-yl)-1H-indazole hydrochloride

Procedure

The title compound was prepared according to the procedure as described in Example 57 reacting 6-bromo-3-methoxy-1-phenyl-1H-indazole and 1-pyridin-4-yl-piperazine, followed by de-protection with HCl.

Sources & evidence

ORD record
ord-41bcfca106a847c68415595eaf259f00
Source dataset
uspto-grants-2014_09
Patent number
US08822447B2

Reaction notes

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