Trifluoroacetic acid → Trifluoroacetic acid

HRID 68766Notes

Reaction equation

HRID 68766 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH:29]2[CH2:31][CH2:30]2)[C:15](=[O:28])[C:16]2[CH:21]=[CH:20][C:19]([C:22]3[O:26][CH:25]=[N:24][C:23]=3[CH3:27])=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35]>>[CH:29]1([N:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:15](=[O:28])[C:16]2[CH:17]=[CH:18][C:19]([C:22]3[O:26][CH:25]=[N:24][C:23]=3[CH3:27])=[CH:20][CH:21]=2)[CH2:31][CH2:30]1.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 682898924-{Cyclopropyl-[4-(4-methyl-oxazol-5-yl)-benzoyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester

Product 2

HCID 6422Trifluoroacetic acidHCID 68289917HCID 68289917, compound

Procedure

A mixture of 4-{cyclopropyl-[4-(4-methyl-oxazol-5-yl)-benzoyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester (180 mg) and trifluoroacetic acid (20% in dichloromethane) is stirred for 1 h at room temperature. The solvent is evaporated to give the title compound as its trifluoroacetic acid salt. Mass spectrum (ESI+): m/z=326 [M+H]+.

Workup

  1. customThe solvent is evaporated

Sources & evidence

ORD record
ord-f8d90795529c4936bda47a00fc657b43
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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