反应详情

温度

120 °C

A mixture of N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrogen chloride salt (52 mg), ethyldiisopropylamine (59 mg), and 2-chloro-5-ethylpyrimidine (21 mg) in N,N-dimethylformamide (1.0 mL) and 1,4-dioxane (1.5 mL) is stirred over night at 120° C. After cooling to room temperature, the solvents are evaporated and the residue is purified by HPLC (H2O/MeOH/TFA) to give the title compound. LC (method 9): tR=1.74 min; Mass spectrum (ESI+): m/z=418 [M+H]+.

1. temperatureAfter cooling to room temperature
2. customthe solvents are evaporated
3. customthe residue is purified by HPLC (H2O/MeOH/TFA)