2,5-Dichloropyrimidine → HCID 68290045, compound

HRID 68841Notes

Reaction equation

HRID 68841 reaction equation
FC(F)(F)C(O)=O.[CH:8]1([N:11]([CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[C:12](=[O:25])[C:13]2[CH:18]=[CH:17][C:16]([C:19]3[O:23][CH:22]=[N:21][C:20]=3[CH3:24])=[CH:15][CH:14]=2)[CH2:10][CH2:9]1.Cl[C:33]1[N:38]=[CH:37][C:36]([Cl:39])=[CH:35][N:34]=1>CN1CCCC1=O>[Cl:39][C:36]1[CH:35]=[N:34][C:33]([N:29]2[CH2:30][CH2:31][CH:26]([N:11]([CH:8]3[CH2:10][CH2:9]3)[C:12](=[O:25])[C:13]3[CH:14]=[CH:15][C:16]([C:19]4[O:23][CH:22]=[N:21][C:20]=4[CH3:24])=[CH:17][CH:18]=3)[CH2:27][CH2:28]2)=[N:38][CH:37]=1

Participants

4

Reactant 2

HCID 5906412,5-DichloropyrimidineHCID 68289916HCID 68289916, compound

Product 1

HCID 68290045HCID 68290045, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The title compound is prepared from N-cyclopropyl-4-(4-methyl-oxazol-5-yl)-N-piperidin-4-yl-benzamide trifluoroacetic acid salt and 2,5-dichloro-pyrimidine following a procedure analogous to that described in Example 19 using N-methylpyrrolidinone as solvent. LC (method 6): tR=1.92 min; Mass spectrum (ESI+): m/z=438/440 (Cl) [M+H]+.

Sources & evidence

ORD record
ord-0206d61a5c8f4c698dd41f9d83e91f0e
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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