3-Chloro-2,5-dimethylpyrazine → HCID 68290682, compound

HRID 68877Notes

Reaction equation

HRID 68877 reaction equation
Cl.[CH:2]1([N:5]([CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[C:6](=[O:18])[C:7]2[CH:12]=[CH:11][C:10]([C:13]3[O:17][CH:16]=[N:15][CH:14]=3)=[CH:9][CH:8]=2)[CH2:4][CH2:3]1.Cl[C:26]1[C:27]([CH3:33])=[N:28][CH:29]=[C:30]([CH3:32])[N:31]=1>CN1CCCC1=O>[CH:2]1([N:5]([CH:19]2[CH2:24][CH2:23][N:22]([C:29]3[C:30]([CH3:32])=[N:31][CH:26]=[C:27]([CH3:33])[N:28]=3)[CH2:21][CH2:20]2)[C:6](=[O:18])[C:7]2[CH:8]=[CH:9][C:10]([C:13]3[O:17][CH:16]=[N:15][CH:14]=3)=[CH:11][CH:12]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 667713-Chloro-2,5-dimethylpyrazineHCID 68289930N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride

Product 1

HCID 68290682HCID 68290682, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride and 3-chloro-2,5-dimethyl-pyrazine following a procedure analogous to that described in Example 19 using N-methylpyrrolidinone as solvent. LC (method 16): tR=0.44 min; Mass spectrum (ESI+): m/z=418 [M+H]+.

Sources & evidence

ORD record
ord-cfab1e2425864cb3b9cc5746d7165396
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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