Water → 1-O-tert-butyl 2-O-methyl 4-(3-bromo-7-methoxyquinolin-2-yl)oxypyrrolidine-1,2-dicarboxylate

HRID 689058Notes

Reaction equation

HRID 689058 reaction equation
[Br:15][c:16]1[cH:17][cH:18][c:19]([S:20]([O:21][CH:26]2[CH2:27][CH:28]([C:38](=[O:39])[O:40][CH3:41])[N:29]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:30]2)(=[O:22])=[O:23])[cH:24][cH:25]1.[Br:1][c:2]1[c:3](=[O:14])[nH:4][c:5]2[cH:6][c:7]([O:12][CH3:13])[cH:8][cH:9][c:10]2[cH:11]1.[C:42](=[O:43])([O-:44])[O-:45].[CH3:48][CH2:49][O:50][C:51]([CH3:52])=[O:53].[CH3:54][N:55]1[CH2:56][CH2:57][CH2:58][C:59]1=[O:60].[Cs+:46].[Cs+:47].[OH2:61]>>[Br:1][c:2]1[c:3]([O:14][CH:26]2[CH2:27][CH:28]([C:38](=[O:39])[O:40][CH3:41])[N:29]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:30]2)[n:4][c:5]2[cH:6][c:7]([O:12][CH3:13])[cH:8][cH:9][c:10]2[cH:11]1

Participants

8

Reactant 7

HCID 962WaterHCID 8857Ethyl AcetateHCID 13387N-methyl-2-pyrrolidoneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 20752709HCID 20752709, compoundHCID 59287022HCID 59287022, compound

Product 1

HCID 722466421-O-tert-butyl 2-O-methyl 4-(3-bromo-7-methoxyquinolin-2-yl)oxypyrrolidine-1,2-dicarboxylate

Sources & evidence

ORD record
ord-4b913de7b16d44b0b05f31bc98550f4d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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