反应详情

Under N2 in a round-bottomed flask fitted with a reflux condenser and magnetic stirrer were placed 6.37 g (19.55 mmol) of cesium carbonate and 3.2 g (19.55 mmol) of 3,4-dichlorophenol (both from Aldrich Chem. Co., Milwaukee, Wis.) in 60 mL of anhydrous toluene. After stirring the mixture for 5 min., 89 mg (0.24 mmol) of copper (II) trifluoromethanesulfonate (copper triflate) and 0.26g (9.78 mmol) of 5-fluoro-2-iodobenzoic acid (prepared according to the method in Collection of Czechoslovakian Chemical Communications, 1975, vol. 40, p728) were added and the mixture was heated to reflux overnight. Progress of the reaction was monitored using thin layer chromatography (tic), eluting with CHCl3:CH3OH:AcOH (9:1:0.5). After allowing the reaction to cool to room temperature, the mixture was diluted with water and EtOAc; the aqueous layer was acidified with 6 N HCl and re-extracted with additional EtOAc. The organic layers were combined, washed with H2O and saturated NaCl and dried over MgSO4. Removal of the solvent in vacuo gave a dark brown colored oil, 2.6 g, as a mixture of title product and unreacted 5-fluoro-2-iodobenzoic acid.

1. customUnder N2 in a round-bottomed flask fitted with a reflux condenser and magnetic stirrer
2. customaccording to the method in Collection of Czechoslovakian Chemical Communications, 1975, vol. 40, p728)
3. additionwere added
4. temperaturethe mixture was heated
5. temperatureto reflux overnight
6. washeluting with CHCl3:CH3OH:AcOH (9:1:0.5)
7. customthe reaction
8. extractionre-extracted with additional EtOAc
9. washwashed with H2O and saturated NaCl
10. dry with materialdried over MgSO4
11. customRemoval of the solvent in vacuo
12. customgave a dark brown colored oil, 2.6 g