反应详情

2-Nitro-N-(2-pyridin-3-ylethyl)benzenesulfonamide (308 mg), and potassium carbonate (276 mg) were added to a DMF solution (5 ml) of 6-(5-bromopentyloxy)-1-methyl-1H-quinolin-2-one (348 mg). The mixture was stirred at room temperature for 2 hours. Ice water was poured to the reaction mixture, followed by extraction using ethyl acetate. The organic layer was washed with water, dried with anhydrous sodium sulfate, and condensed under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate→ethyl acetate:methanol=10:1). The purified product was condensed to dryness under reduced pressure to give 5 the title compound (535 mg) as a yellow amorphous solid.

1. extractionfollowed by extraction
2. washThe organic layer was washed with water
3. dry with materialdried with anhydrous sodium sulfate, and condensed under reduced pressure
4. customThe residue was purified by silica gel column chromatography (ethyl acetate→ethyl acetate:methanol=10:1)
5. customcondensed to dryness under reduced pressure