反应详情

温度

80 °C

2N Hydrochloric acid (10 ml) was added to a DMF solution (5 ml) of 4-chloro-(3-pyridin-3-yl)quinoline (0.51 g), and the mixture was stirred at 80° C. for 1 hour. After the reaction mixture was cooled to room temperature, 2N sodium hydroxide aqueous solution (10 ml) was added dropwise under ice cooling. The mixture was stirred. The precipitated insoluble matter was separated, washed with water and ether, and dried to give the title compound (0.35 g) as a pale whitish purple powder.

1. temperatureAfter the reaction mixture was cooled to room temperature
2. stirringThe mixture was stirred
3. customThe precipitated insoluble matter was separated
4. washwashed with water and ether
5. customdried