Hydrochloric Acid → tert-Butyl 3-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-5-fluorophenyl)-3-oxopropyl(methyl)carbamate

HRID 690896Notes

Reaction equation

HRID 690896 reaction equation
[Br:1][c:2]1[c:3]([C:9]2=[N:13][C:12]([CH3:14])([CH3:15])[CH2:11][O:10]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[C:16]([Li:17])([CH3:18])([CH3:19])[CH3:20].[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[CH3:21][O:22][N:23]([C:24]([CH2:25][CH2:26][N:27]([C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[CH3:35])=[O:36])[CH3:37].[ClH:38]>>[c:2]1([C:24]([CH2:25][CH2:26][N:27]([C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[CH3:35])=[O:36])[c:3]([C:9]2=[N:13][C:12]([CH3:14])([CH3:15])[CH2:11][O:10]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 59364357Tert-butyl 3-(methoxy(methyl)amino)-3-oxopropyl(methyl)carbamateHCID 593643802-(2-Bromo-4-fluorophenyl)-4,4-dimethyl-4,5-dihydrooxazoleHCID 178418306HCID 178418306, compound

Product 1

HCID 59364358tert-Butyl 3-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-5-fluorophenyl)-3-oxopropyl(methyl)carbamate

Sources & evidence

ORD record
ord-c44688062db944e68fbd7b7f82d21a30
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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