Dimethylformamide → N1-(3-Fluoro-4-hydroxyphenyl)-N3-(4-fluorophenyl)malonamide

HRID 691091Notes

Reaction equation

HRID 691091 reaction equation
[CH3:15][CH2:16][N:17]([CH2:18][CH3:19])[CH2:20][CH3:21].[CH3:31][N:32]([CH3:33])[CH:34]=[O:35].[F:1][c:2]1[cH:3][cH:4][c:5]([NH:8][C:9]([CH2:10][C:11](=[O:12])[OH:13])=[O:14])[cH:6][cH:7]1.[NH2:22][c:23]1[cH:24][c:25]([F:30])[c:26]([OH:29])[cH:27][cH:28]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([NH:8][C:9]([CH2:10][C:11](=[O:13])[NH:22][c:23]2[cH:24][c:25]([F:30])[c:26]([OH:29])[cH:27][cH:28]2)=[O:14])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 2735918Phenol, 4-amino-2-fluoro-HCID 43418433-(4-Fluorophenylamino)-3-oxopropanoic acid

Product 1

HCID 44203043N1-(3-Fluoro-4-hydroxyphenyl)-N3-(4-fluorophenyl)malonamide

Sources & evidence

ORD record
ord-9238483caefa482ea1d89dd50e2c1965
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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