Dimethylformamide → 4{2-[(trans-4-Hydroxycyclohexyl)amino]quinazolin-8-yl}phenol
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[cH:7][n:8][c:9]([NH:12][CH:13]3[CH2:14][CH2:15][CH:16]([OH:19])[CH2:17][CH2:18]3)[n:10][c:11]12.[O:107]=[CH:108][N:109]([CH3:110])[CH3:111].[OH:20][c:21]1[cH:22][cH:23][c:24]([B:27]([OH:28])[OH:29])[cH:25][cH:26]1.[cH:30]1[cH:31][cH:32][c:33]([P:34]([Pd:35]([P:36]([c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)([c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)([P:55]([c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[P:74]([c:75]2[cH:76][cH:77][cH:78][cH:79][cH:80]2)([c:81]2[cH:82][cH:83][cH:84][cH:85][cH:86]2)[c:87]2[cH:88][cH:89][cH:90][cH:91][cH:92]2)([c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)[c:99]2[cH:100][cH:101][cH:102][cH:103][cH:104]2)[cH:105][cH:106]1>>[c:2]1(-[c:24]2[cH:23][cH:22][c:21]([OH:20])[cH:26][cH:25]2)[cH:3][cH:4][cH:5][c:6]2[cH:7][n:8][c:9]([NH:12][CH:13]3[CH2:14][CH2:15][CH:16]([OH:19])[CH2:17][CH2:18]3)[n:10][c:11]12Participants
5
Sources & evidence
- ORD record
- ord-881e239b61094517ad371e4aa4658a71
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
Loading…