Trifluoroacetic acid → 6-bromo-3,3-dimethyl-4-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

HRID 692429Notes

Reaction equation

HRID 692429 reaction equation
[Br:8][c:9]1[c:10]([NH:16][C:17]([C:18]([CH3:19])([NH:20][CH2:21][CH2:22][CH:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[CH3:29])=[O:30])[n:11][cH:12][c:13]([Br:15])[n:14]1.[CH2:40]1[O:41][CH2:42][CH2:43][O:44][CH2:45]1.[CH:31]([N:32]([CH2:33][CH3:34])[CH:35]([CH3:36])[CH3:37])([CH3:38])[CH3:39].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[c:9]12[c:10]([n:11][cH:12][c:13]([Br:15])[n:14]1)[NH:16][C:17](=[O:30])[C:18]([CH3:19])([CH3:29])[N:20]2[CH2:21][CH2:22][CH:23]1[CH2:24][CH2:25][O:26][CH2:27][CH2:28]1

Participants

5

Reactant 4

HCID 6422Trifluoroacetic acidHCID 312751,4-DioxaneHCID 81531DiisopropylethylamineHCID 86696612N-(3,5-dibromopyrazin-2-yl)-2-methyl-2-[2-(oxan-4-yl)ethylamino]propanamide

Product 1

HCID 533752276-bromo-3,3-dimethyl-4-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

Sources & evidence

ORD record
ord-8c8e0c29b4d0444981a14b6bcf3f8207
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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