Dimethylformamide → Ethyl 2-(naphthalen-1-ylsulfonylamino)-3-[6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl]purin-9-yl]propanoate

HRID 692612Notes

Reaction equation

HRID 692612 reaction equation
[CH:48]([N:49]([CH:50]([CH3:51])[CH3:52])[CH2:53][CH3:54])([CH3:55])[CH3:56].[Cl:1][c:2]1[c:3]2[n:4][cH:5][n:6]([CH2:11][CH:12]([C:13](=[O:14])[O:15][CH2:16][CH3:17])[NH:18][S:19](=[O:20])(=[O:21])[c:22]3[cH:23][cH:24][cH:25][c:26]4[cH:27][cH:28][cH:29][cH:30][c:31]34)[c:7]2[n:8][cH:9][n:10]1.[NH:32]1[CH2:33][CH2:34][CH:35]([c:38]2[cH:39][cH:40][c:41]3[c:46]([n:47]2)[NH:45][CH2:44][CH2:43][CH2:42]3)[CH2:36][CH2:37]1.[O:57]=[CH:58][N:59]([CH3:60])[CH3:61]>>[c:2]1([N:32]2[CH2:33][CH2:34][CH:35]([c:38]3[cH:39][cH:40][c:41]4[c:46]([n:47]3)[NH:45][CH2:44][CH2:43][CH2:42]4)[CH2:36][CH2:37]2)[c:3]2[n:4][cH:5][n:6]([CH2:11][CH:12]([C:13](=[O:14])[O:15][CH2:16][CH3:17])[NH:18][S:19](=[O:20])(=[O:21])[c:22]3[cH:23][cH:24][cH:25][c:26]4[cH:27][cH:28][cH:29][cH:30][c:31]34)[c:7]2[n:8][cH:9][n:10]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 113903267-(4-Piperidinyl)-1,2,3,4-tetrahydro[1,8]naphthyridineHCID 23594200Ethyl 3-(6-chloropurin-9-yl)-2-(naphthalen-1-ylsulfonylamino)propanoate

Product 1

HCID 23594201Ethyl 2-(naphthalen-1-ylsulfonylamino)-3-[6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl]purin-9-yl]propanoate

Sources & evidence

ORD record
ord-a98b20d0e80d4f09af7786ce4302452f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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