Dichloromethane → 1-Oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid [4-amino-5-(3-hydroxy-3-methyl-butyl)-2'-trifluoromethyl-biphenyl-3-yl]-amide
Reaction equation
[CH:25]([N:26]([CH2:27][CH3:28])[CH:29]([CH3:30])[CH3:31])([CH3:32])[CH3:33].[Cl:47][CH2:48][Cl:49].[NH2:1][c:2]1[c:3]([CH2:19][CH2:20][C:21]([CH3:22])([OH:23])[CH3:24])[cH:4][c:5](-[c:9]2[c:10]([C:15]([F:16])([F:17])[F:18])[cH:11][cH:12][cH:13][cH:14]2)[cH:6][c:7]1[NH2:8].[O:34]1[N:35]=[C:36]([C:44](=[O:45])[OH:46])[CH2:37][C:38]12[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]2>>[NH2:1][c:2]1[c:3]([CH2:19][CH2:20][C:21]([CH3:22])([OH:23])[CH3:24])[cH:4][c:5](-[c:9]2[c:10]([C:15]([F:16])([F:17])[F:18])[cH:11][cH:12][cH:13][cH:14]2)[cH:6][c:7]1[NH:8][C:44]([C:36]1=[N:35][O:34][C:38]2([CH2:37]1)[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]2)=[O:45]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-e713eb4234c045488904e4c382c52be1
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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