Ammonia → 1-[2-(2-Chloro-benzylamino)-pyrido[4,3-d]pyrimidin-5-yl]-piperidine-4-carboxylic acid ethyl ester

HRID 693718Notes

Reaction equation

HRID 693718 reaction equation
[CH2:21]([CH3:22])[O:23][C:24](=[O:25])[CH:26]1[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]1.[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[Cl:1][c:2]1[c:3]([CH2:4][NH:5][c:6]2[n:7][cH:8][c:9]3[c:10]([n:11]2)[cH:12][cH:13][n:14][c:15]3[Cl:16])[cH:17][cH:18][cH:19][cH:20]1.[NH3:32].[OH2:33]>>[Cl:1][c:2]1[c:3]([CH2:4][NH:5][c:6]2[n:7][cH:8][c:9]3[c:10]([n:11]2)[cH:12][cH:13][n:14][c:15]3[N:29]2[CH2:28][CH2:27][CH:26]([C:24]([O:23][CH2:21][CH3:22])=[O:25])[CH2:31][CH2:30]2)[cH:17][cH:18][cH:19][cH:20]1

Participants

6

Reactant 5

HCID 222AmmoniaHCID 962WaterHCID 8028TetrahydrofuranHCID 70770Ethyl 4-piperidinecarboxylateHCID 58450134(2-Chloro-benzyl)-(5-chloro-pyrido[4,3-d]pyrimidin-2-yl)-amine

Product 1

HCID 584501201-[2-(2-Chloro-benzylamino)-pyrido[4,3-d]pyrimidin-5-yl]-piperidine-4-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-d8504693761d4095acc7b8f29852dae8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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