Trifluoroacetic acid → N-{5-[(5-amino-2-chloro-4-fluorophenyl)amino][1,3]thiazolo[5,4-d]pyrimidin-2-yl}acetamide

HRID 693879Notes

Reaction equation

HRID 693879 reaction equation
[C:1]([N:5]([C:2](=[O:3])[O-:4])[c:9]1[c:10]([F:30])[cH:11][c:12]([Cl:29])[c:13]([NH:15][c:16]2[n:17][cH:18][c:19]3[c:20]([n:21]2)[s:22][c:23]([NH:25][C:26]([CH3:27])=[O:28])[n:24]3)[cH:14]1)([CH3:6])([CH3:7])[CH3:8].[CH3:31][O:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1.[OH:39][C:40]([C:41]([F:42])([F:43])[F:44])=[O:45]>>[NH2:5][c:9]1[c:10]([F:30])[cH:11][c:12]([Cl:29])[c:13]([NH:15][c:16]2[n:17][cH:18][c:19]3[c:20]([n:21]2)[s:22][c:23]([NH:25][C:26]([CH3:27])=[O:28])[n:24]3)[cH:14]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 178474400N-[5-[(2-acetamido-[1,3]thiazolo[5,4-d]pyrimidin-5-yl)amino]-4-chloro-2-fluorophenyl]-N-tert-butylcarbamate

Product 1

HCID 86646101N-{5-[(5-amino-2-chloro-4-fluorophenyl)amino][1,3]thiazolo[5,4-d]pyrimidin-2-yl}acetamide

Sources & evidence

ORD record
ord-bc4b9750e1dc48e48809b99d79c66724
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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