Sodium ion → 1'-methyl-4'-morpholin-4-yl-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one
Reaction equation
[Br:1][c:2]1[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[N:8]([CH3:24])[C:9](=[O:23])[C:10]21[CH2:11][O:12][c:13]2[cH:14][c:15]3[c:16]([cH:21][c:22]21)[O:17][CH2:18][CH2:19][O:20]3.[CH2:25]1[CH2:26][O:27][CH2:28][CH2:29][NH:30]1.[CH3:31][C:32]([CH3:33])([O-:34])[CH3:35].[CH3:37][C:38]1([CH3:39])[c:40]2[cH:41][cH:42][cH:43][c:44]([P:45]([c:46]3[cH:47][cH:48][cH:49][cH:50][cH:51]3)[c:52]3[cH:53][cH:54][cH:55][cH:56][cH:57]3)[c:58]2[O:59][c:60]2[c:61]1[cH:62][cH:63][cH:64][c:65]2[P:66]([c:67]1[cH:68][cH:69][cH:70][cH:71][cH:72]1)[c:73]1[cH:74][cH:75][cH:76][cH:77][cH:78]1.[CH3:79][c:80]1[cH:81][cH:82][cH:83][cH:84][cH:85]1.[CH3:86][CH2:87][O:88][C:89](=[O:90])[CH3:91].[Na+:36].[O:112]=[C:113]([CH:114]=[CH:115][c:116]1[cH:117][cH:118][cH:119][cH:120][cH:121]1)[CH:122]=[CH:123][c:124]1[cH:125][cH:126][cH:127][cH:128][cH:129]1.[O:130]=[C:131]([CH:132]=[CH:133][c:134]1[cH:135][cH:136][cH:137][cH:138][cH:139]1)[CH:140]=[CH:141][c:142]1[cH:143][cH:144][cH:145][cH:146][cH:147]1.[O:94]=[C:95]([CH:96]=[CH:97][c:98]1[cH:99][cH:100][cH:101][cH:102][cH:103]1)[CH:104]=[CH:105][c:106]1[cH:107][cH:108][cH:109][cH:110][cH:111]1.[Pd:92].[Pd:93]>>[c:2]1([N:30]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[N:8]([CH3:24])[C:9](=[O:23])[C:10]21[CH2:11][O:12][c:13]2[cH:14][c:15]3[c:16]([cH:21][c:22]21)[O:17][CH2:18][CH2:19][O:20]3Participants
10
Reactant 9
HCID 923Sodium ion
HCID 1140Toluene
HCID 8083Morpholine
HCID 8857Ethyl Acetate
HCID 23938Palladium2×
HCID 95417Dibenzylidene acetone3×
HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)
HCID 45749132-Methylpropan-2-olate
HCID 593527794'-bromo-1'-methyl-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1H)-oneProduct 1
Sources & evidence
- ORD record
- ord-aec13a26329f4549967a494f07bddf57
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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