反应详情

A mixture of 2-chloro-1-fluoro-4-nitrobenzene (4.79 g), dimethylpyrrolidin-3-ylamine (2.60 g), potassium carbonate (3.82 g) and DMF (35 mL) was stirred at room temperature for 4 hours. The reaction mixture was partitioned between water and ethyl acetate. The organic phase was extracted with hydrochloric acid (2 M), and the extract was basified with sodium hydroxide solution (2M). Extraction with ethyl acetate afforded an organic phase which was dried and concentrated. The product with the molecular weight of 269.73 (C12H16ClN3O2) was obtained in this way; MS (ESI): 270 (M+H+).

1. customThe reaction mixture was partitioned between water and ethyl acetate
2. extractionThe organic phase was extracted with hydrochloric acid (2 M)
3. extractionExtraction with ethyl acetate
4. customafforded an organic phase which
5. customwas dried
6. concentrationconcentrated
7. customThe product with the molecular weight of 269.73 (C12H16ClN3O2) was obtained in this way