反应详情

温度

50 °C

Triethylamine (1.0 g) and then Pd(dppf)Cl2 (365 mg) were added to a mixture of trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester (2.5 g), DMF (50 mL) and methanol (25 mL). The mixture was heated at 50° C. in an autoclave under a CO atmosphere (5 bar) for 6 hours. The cooled and decompressed reaction mixture was partitioned between water and ethyl acetate. The organic phase was dried over sodium sulfate and concentrated. The residue was purified by preparative HPLC. The product with the molecular weight of 411.48 (C23H26FN3O3) was obtained in this way; MS (ESI): 412 (M+H+).

1. temperatureThe cooled
2. customreaction mixture
3. customwas partitioned between water and ethyl acetate
4. dry with materialThe organic phase was dried over sodium sulfate
5. concentrationconcentrated
6. customThe residue was purified by preparative HPLC
7. customThe product with the molecular weight of 411.48 (C23H26FN3O3) was obtained in this way