Dichloromethane → methyl 2-(6-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)acetate

HRID 694312Notes

Reaction equation

HRID 694312 reaction equation
[Br:36][CH2:37][C:38](=[O:39])[O:40][CH3:41].[CH3:29][CH2:30][N:31]([CH2:32][CH3:33])[CH2:34][CH3:35].[Cl:42][CH2:43][Cl:44].[c:1]1([C:7]2([c:10]3[cH:11][cH:12][c:13]4[c:14]([n:15]3)[s:16][c:17](-[c:19]3[cH:20][c:21]5[c:26]([cH:27][cH:28]3)[CH2:25][NH:24][CH2:23][CH2:22]5)[n:18]4)[CH2:8][CH2:9]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([C:7]2([c:10]3[cH:11][cH:12][c:13]4[c:14]([n:15]3)[s:16][c:17](-[c:19]3[cH:20][c:21]5[c:26]([cH:27][cH:28]3)[CH2:25][N:24]([CH2:37][C:38](=[O:39])[O:40][CH3:41])[CH2:23][CH2:22]5)[n:18]4)[CH2:8][CH2:9]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 60984Methyl bromoacetateHCID 591748385-(1-Phenylcyclopropyl)-2-(1,2,3,4-tetrahydroisoquinolin-6-yl)thiazolo[5,4-b]pyridine

Product 1

HCID 67112976methyl 2-(6-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)acetate

Sources & evidence

ORD record
ord-f4e1e167708540b99fa23c208f2e3216
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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