Dichloromethane → N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-7-(5-piperidin-1-ylpent-2-ynoyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]-thieno[2,3-d]pyrimidin-4-amine

HRID 694390Notes

Reaction equation

HRID 694390 reaction equation
[B-:43]([F:44])([F:45])([F:46])[F:47].[CH:65]([N:66]([CH:67]([CH3:68])[CH3:69])[CH2:70][CH3:71])([CH3:72])[CH3:73].[Cl:1][c:2]1[cH:3][c:4]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[s:22][c:23]4[c:28]([c:29]23)[CH2:27][CH2:26][NH:25][CH2:24]4)[cH:5][cH:6][c:7]1[O:8][CH2:9][c:10]1[n:11][cH:12][cH:13][cH:14][cH:15]1.[Cl:79][CH2:80][Cl:81].[N:30]1([CH2:36][CH2:37][C:38]#[C:39][C:40](=[O:41])[OH:42])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1.[O:74]1[CH2:75][CH2:76][CH2:77][CH2:78]1.[n:48]1([O:49][C:50]([N:51]([CH3:52])[CH3:53])=[N+:54]([CH3:55])[CH3:56])[c:57]2[cH:58][cH:59][cH:60][cH:61][c:62]2[n:63][n:64]1>>[Cl:1][c:2]1[cH:3][c:4]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[s:22][c:23]4[c:28]([c:29]23)[CH2:27][CH2:26][N:25]([C:40]([C:39]#[C:38][CH2:37][CH2:36][N:30]2[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]2)=[O:41])[CH2:24]4)[cH:5][cH:6][c:7]1[O:8][CH2:9][c:10]1[n:11][cH:12][cH:13][cH:14][cH:15]1

Participants

8

Reactant 7

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 26255TetrafluoroborateHCID 81531DiisopropylethylamineHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 117011425-Piperidin-1-yl-pent-2-ynoic acidHCID 59586947[3-Chloro-4-(pyridin-2-ylmethoxy)-phenyl]-(5,6,7,8-tetrahydro-9-thia-1,3,7-triaza-fluoren-4-yl)amine

Product 1

HCID 59586894N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-7-(5-piperidin-1-ylpent-2-ynoyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]-thieno[2,3-d]pyrimidin-4-amine

Sources & evidence

ORD record
ord-f73f5d9f180c4d92b5cb653e45b5ed45
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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