反应详情

温度

75 °C

Potassium carbonate (6.9 g) was added to a mixture of 3,4-difluoronitrobenzene (8.0 g) and 1,4-dioxa-7-aza-spiro[4.4]nonane (12.9 g) in acetonitrile (34.6 mL) and the reaction mixture was heated for 2 h at 75° C. Ethyl acetate and water were added to the reaction mixture. The aqueous phase was extracted several times with ethyl acetate. The organic phases were combined, dried over sodium sulfate and the solvent was removed in vacuum. In this way the product was obtained with molecular weight 268.24 (C12H13FN2O4); MS (ESI): 269 (M+H+).

1. extractionThe aqueous phase was extracted several times with ethyl acetate
2. dry with materialdried over sodium sulfate
3. customthe solvent was removed in vacuum
4. customIn this way the product was obtained with molecular weight 268.24 (C12H13FN2O4)