1,2-Dichloroethane → 6-Fluoroquinolin-3-amine

HRID 694754Notes

Reaction equation

HRID 694754 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][c:8]1[cH:9][n:10][c:11]2[cH:12][cH:13][c:14]([F:18])[cH:15][c:16]2[cH:17]1)([CH3:5])([CH3:6])[CH3:19].[Cl:28][CH2:29][CH2:30][Cl:31].[OH2:27].[OH:20][C:21]([C:22]([F:23])([F:24])[F:25])=[O:26]>>[NH2:7][c:8]1[cH:9][n:10][c:11]2[cH:12][cH:13][c:14]([F:18])[cH:15][c:16]2[cH:17]1

Participants

5

Reactant 4

HCID 111,2-DichloroethaneHCID 962WaterHCID 6422Trifluoroacetic acidHCID 66815651(6-Fluoro-quinolin-3-yl)carbamic acid tert-butyl ester

Product 1

HCID 224587126-Fluoroquinolin-3-amine

Sources & evidence

ORD record
ord-96f9f94c474c4f6ba3685ef16ace809f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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