Ammonium → 6-Tert-butyl-2-chloropyridine-3-carbonitrile

HRID 694927Notes

Reaction equation

HRID 694927 reaction equation
[Ag+:41].[CH3:10][C:11]([CH3:12])([CH3:13])[C:14](=[O:15])[OH:16].[Cl:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][cH:7][cH:8][n:9]1.[N+:37]([O-:38])([O-:39])=[O:40].[NH4+:27].[NH4+:28].[NH4+:30].[OH-:29].[OH2:36].[S:17]([O:18][O:19][S:20]([O-:21])(=[O:22])=[O:23])([O-:24])(=[O:25])=[O:26].[S:31](=[O:32])(=[O:33])([OH:34])[OH:35]>>[Cl:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][cH:7][c:8]([C:11]([CH3:10])([CH3:12])[CH3:13])[n:9]1

Participants

10

Reactant 9

HCID 223Ammonium3×HCID 943NitrateHCID 961HydroxideHCID 962WaterHCID 1118Sulfuric AcidHCID 6417Pivalic acidHCID 810792-ChloronicotinonitrileHCID 104755Silver cationHCID 107879Peroxydisulfate

Product 1

HCID 532788766-Tert-butyl-2-chloropyridine-3-carbonitrile

Sources & evidence

ORD record
ord-9afc5dd799c34c819311345e7e3c549c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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