Dimethylformamide → 4-(4-cyclopropylimidazol-1-yl)-N-[2-[4-(1,1,1-trifluoropropan-2-yl)-1,2,4-triazol-3-yl]-1,3-thiazol-4-yl]pyridine-2-carboxamide

HRID 695946Notes

Reaction equation

HRID 695946 reaction equation
[CH3:59][N:60]1[CH2:61][CH2:62][O:63][CH2:64][CH2:65]1.[CH3:66][N:67]([CH3:68])[CH:69]=[O:70].[CH:1]1([c:4]2[n:5][cH:6][n:7](-[c:9]3[cH:10][c:11]([C:15](=[O:16])[OH:17])[n:12][cH:13][cH:14]3)[cH:8]2)[CH2:2][CH2:3]1.[F:18][C:19]([CH:20]([CH3:21])[n:22]1[c:23](-[c:27]2[s:28][cH:29][c:30]([NH2:32])[n:31]2)[n:24][n:25][cH:26]1)([F:33])[F:34].[P-:35]([F:36])([F:37])([F:38])([F:39])([F:40])[F:41].[n:42]1([O:43][C:44]([N:45]([CH3:46])[CH3:47])=[N+:48]([CH3:49])[CH3:50])[c:51]2[n:52][cH:53][cH:54][cH:55][c:56]2[n:57][n:58]1>>[CH:1]1([c:4]2[n:5][cH:6][n:7](-[c:9]3[cH:10][c:11]([C:15](=[O:17])[NH:32][c:30]4[cH:29][s:28][c:27](-[c:23]5[n:22]([CH:20]([C:19]([F:18])([F:33])[F:34])[CH3:21])[cH:26][n:25][n:24]5)[n:31]4)[n:12][cH:13][cH:14]3)[cH:8]2)[CH2:2][CH2:3]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 79724-MethylmorpholineHCID 9886HexafluorophosphateHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 580356504-(4-cyclopropyl-1H-imidazol-1-yl)picolinic acidHCID 580356582-[4-(1,1,1-Trifluoropropan-2-yl)-1,2,4-triazol-3-yl]-1,3-thiazol-4-amine

Product 1

HCID 565990414-(4-cyclopropylimidazol-1-yl)-N-[2-[4-(1,1,1-trifluoropropan-2-yl)-1,2,4-triazol-3-yl]-1,3-thiazol-4-yl]pyridine-2-carboxamide

Sources & evidence

ORD record
ord-7ea9e4143bf449569733b85d4d48c421
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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