1-Bromo-4-fluorobenzene → 8-(1-(4-fluorophenyl)pyrrolidin-2-yl)-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one
Reaction equation
[Br:56][c:57]1[cH:58][cH:59][c:60]([F:63])[cH:61][cH:62]1.[C:64](=[O:65])([O-:66])[O-:67].[C:76]([O:77][Pd:78][O:79][C:80](=[O:81])[CH3:82])(=[O:83])[CH3:84].[CH2:70]1[O:71][CH2:72][CH2:73][O:74][CH2:75]1.[Cs+:68].[Cs+:69].[O:1]1[CH2:2][CH2:3][N:4]([C:7](=[O:8])[c:9]2[cH:10][c:11]3[c:12](=[O:30])[cH:13][c:14]([N:24]4[CH2:25][CH2:26][O:27][CH2:28][CH2:29]4)[o:15][c:16]3[c:17]([CH:19]3[NH:20][CH2:21][CH2:22][CH2:23]3)[cH:18]2)[CH2:5][CH2:6]1.[c:31]1(-[c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[cH:38][cH:39][cH:40][cH:41][c:42]1[P:43]([CH:44]1[CH2:45][CH2:46][CH2:47][CH2:48][CH2:49]1)[CH:50]1[CH2:51][CH2:52][CH2:53][CH2:54][CH2:55]1>>[O:1]1[CH2:2][CH2:3][N:4]([C:7](=[O:8])[c:9]2[cH:10][c:11]3[c:12](=[O:30])[cH:13][c:14]([N:24]4[CH2:25][CH2:26][O:27][CH2:28][CH2:29]4)[o:15][c:16]3[c:17]([CH:19]3[N:20]([c:57]4[cH:58][cH:59][c:60]([F:63])[cH:61][cH:62]4)[CH2:21][CH2:22][CH2:23]3)[cH:18]2)[CH2:5][CH2:6]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-22d73f3ae55f4025ab313fe1c0bfab74
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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