Tetrahydrofuran → 3,4-Difluoro-2-[[2-fluoro-4-(trimethylsilylethynyl)phenyl]amino]benzoic acid
Reaction equation
[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:28][Si:29]([N-:30][Si:31]([CH3:32])([CH3:33])[CH3:34])([CH3:35])[CH3:36].[F:15][c:16]1[c:17]([C:18](=[O:19])[OH:20])[cH:21][cH:22][c:23]([F:26])[c:24]1[F:25].[F:1][c:2]1[c:3]([NH2:4])[cH:5][cH:6][c:7]([C:9]#[C:10][Si:11]([CH3:12])([CH3:13])[CH3:14])[cH:8]1.[Li+:27]>>[F:1][c:2]1[c:3]([NH:4][c:16]2[c:17]([C:18](=[O:19])[OH:20])[cH:21][cH:22][c:23]([F:26])[c:24]2[F:25])[cH:5][cH:6][c:7]([C:9]#[C:10][Si:11]([CH3:12])([CH3:13])[CH3:14])[cH:8]1Participants
6
Sources & evidence
- ORD record
- ord-0eedd3ccf67c49b2985bd7d2ede00ed7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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