Tetrahydrofuran → 2-(3-Fluorophenyl)pyrrolidine

HRID 696771Notes

Reaction equation

HRID 696771 reaction equation
[C:15]([c:16]1[cH:17][cH:18][c:19](-[c:20]2[cH:21][cH:22][c:23]([C:24]([CH3:25])([CH3:26])[CH3:27])[cH:28][cH:29]2)[cH:30][cH:31]1)([CH3:32])([CH3:33])[CH3:34].[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[Cl:1][CH2:2][CH2:3][CH2:4][N:5]=[CH:6][c:7]1[cH:8][c:9]([F:13])[cH:10][cH:11][cH:12]1.[Li:14]>>[CH2:2]1[CH2:3][CH2:4][NH:5][CH:6]1[c:7]1[cH:8][c:9]([F:13])[cH:10][cH:11][cH:12]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylHCID 3028194LithiumHCID 58335513HCID 58335513, compound

Product 1

HCID 39124022-(3-Fluorophenyl)pyrrolidine

Sources & evidence

ORD record
ord-5043f127d43b4313971459bbcfaacd9d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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