Dimethylformamide → N-(3-Fluoro-4-{[2-({[methyl(1-methylpiperidin-4-yl)amino]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

HRID 696862Notes

Reaction equation

HRID 696862 reaction equation
[CH3:44][CH2:45][N:46]([CH2:47][CH3:48])[CH2:49][CH3:50].[CH3:78][N:79]([CH3:80])[CH:81]=[O:82].[F:28][c:29]1[cH:30][cH:31][c:32]([NH:35][C:36](=[O:37])[C:38]2([C:41](=[O:42])[OH:43])[CH2:39][CH2:40]2)[cH:33][cH:34]1.[NH2:1][c:2]1[cH:3][c:4]([F:27])[c:5]([O:6][c:7]2[cH:8][c:9]([NH:13][C:14]([N:15]([CH:16]3[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)[CH3:23])=[O:24])[n:10][cH:11][cH:12]2)[cH:25][cH:26]1.[P-:51]([F:52])([F:53])([F:54])([F:55])([F:56])[F:57].[n:58]1([O:59][P+:60]([N:61]([CH3:62])[CH3:63])([N:64]([CH3:65])[CH3:66])[N:67]([CH3:68])[CH3:69])[c:70]2[cH:71][cH:72][cH:73][cH:74][c:75]2[n:76][n:77]1>>[NH:1]([c:2]1[cH:3][c:4]([F:27])[c:5]([O:6][c:7]2[cH:8][c:9]([NH:13][C:14]([N:15]([CH:16]3[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)[CH3:23])=[O:24])[n:10][cH:11][cH:12]2)[cH:25][cH:26]1)[C:41]([C:38]1([C:36]([NH:35][c:32]2[cH:31][cH:30][c:29]([F:28])[cH:34][cH:33]2)=[O:37])[CH2:39][CH2:40]1)=[O:42]

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 9886HexafluorophosphateHCID 124335Benzotriazol-1-yloxy-tris(dimethylamino)phosphoniumHCID 210815301-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic AcidHCID 231535663-[4-(4-Amino-2-fluorophenoxy)pyridin-2-yl]-1-methyl-1-(1-methylpiperidin-4-yl)urea

Product 1

HCID 59596907N-(3-Fluoro-4-{[2-({[methyl(1-methylpiperidin-4-yl)amino]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Sources & evidence

ORD record
ord-7d570b9f54f04b91b77683752eca8872
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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