Dichloromethane → N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-7-{2-[(diethylamino)methyl]acryloyl}-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amine

HRID 697900Notes

Reaction equation

HRID 697900 reaction equation
[B-:41]([F:42])([F:43])([F:44])[F:45].[CH2:30]([CH3:31])[N:32]([CH2:33][CH3:34])[CH2:35][C:36]([C:37](=[O:38])[OH:39])=[CH2:40].[CH:63]([N:64]([CH:65]([CH3:66])[CH3:67])[CH2:68][CH3:69])([CH3:70])[CH3:71].[Cl:1][c:2]1[cH:3][c:4]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[s:22][c:23]4[c:28]([c:29]23)[CH2:27][CH2:26][NH:25][CH2:24]4)[cH:5][cH:6][c:7]1[O:8][CH2:9][c:10]1[n:11][cH:12][cH:13][cH:14][cH:15]1.[Cl:77][CH2:78][Cl:79].[O:72]1[CH2:73][CH2:74][CH2:75][CH2:76]1.[n:46]1([O:47][C:48]([N:49]([CH3:50])[CH3:51])=[N+:52]([CH3:53])[CH3:54])[c:55]2[cH:56][cH:57][cH:58][cH:59][c:60]2[n:61][n:62]1>>[Cl:1][c:2]1[cH:3][c:4]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[s:22][c:23]4[c:28]([c:29]23)[CH2:27][CH2:26][N:25]([C:37]([C:36]([CH2:35][N:32]([CH2:30][CH3:31])[CH2:33][CH3:34])=[CH2:40])=[O:38])[CH2:24]4)[cH:5][cH:6][c:7]1[O:8][CH2:9][c:10]1[n:11][cH:12][cH:13][cH:14][cH:15]1

Participants

8

Reactant 7

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 26255TetrafluoroborateHCID 81531DiisopropylethylamineHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 100121482-Diethylaminomethyl-acrylic acidHCID 59586947[3-Chloro-4-(pyridin-2-ylmethoxy)-phenyl]-(5,6,7,8-tetrahydro-9-thia-1,3,7-triaza-fluoren-4-yl)amine

Product 1

HCID 59586843N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-7-{2-[(diethylamino)methyl]acryloyl}-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amine

Sources & evidence

ORD record
ord-06c4b5172578442394bea152df82fb66
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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