Diisopropylethylamine → HCID 69043589, compound

HRID 69876Notes

Reaction equation

HRID 69876 reaction equation
Br[C:2]1[C:3]([NH2:9])=[N:4][C:5](=[O:8])[NH:6][CH:7]=1.[F:10][CH:11]1[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]1.C(N(C(C)C)CC)(C)C>>[NH2:9][C:3]1[NH:4][C:5](=[O:8])[N:6]=[CH:7][C:2]=1[N:13]1[CH2:14][CH2:15][CH2:16][CH:11]([F:10])[CH2:12]1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 27591573-FluoropiperidineHCID 178509018HCID 178509018, compound

Product 1

HCID 69043589HCID 69043589, compound

Procedure

Method 8 was followed using 1 eq. of 5-bromocytosine, 1.25 eq. of 3-fluoropiperidine and 2.5 eq. of diisopropylethylamine at 120° C. for 2 days yielding 6-amino-5-(3-fluoropiperidin-1-yl)pyrimidin-2(1H)-one as an orange crunchy solid (24%). LCMS (m/z): 213.0 (MH+); LC Rt=1.07 min.

Workup

  1. customat 120° C.
  2. customfor 2 days

Sources & evidence

ORD record
ord-ea72114d63de436a879afc0f32312ef3
Source dataset
uspto-grants-2014_09
Patent number
US08822497B2

Reaction notes

Loading…