Acetate → 2-(4-t-Butylphenyl)-7-(2-pyridin-4-yl-vinyl)-2,3-dihydro-isoindol-1-one

HRID 698837Notes

Reaction equation

HRID 698837 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:10]1[C:9](=[O:11])[N:8]([c:12]1[cH:13][cH:14][c:15]([C:18]([CH3:19])([CH3:20])[CH3:21])[cH:16][cH:17]1)[CH2:7]2.[CH3:61][CH2:62][N:63]([CH2:64][CH3:65])[CH2:66][CH3:67].[CH:22](=[CH2:23])[c:24]1[cH:25][cH:26][n:27][cH:28][cH:29]1.[O-:53][C:54]([CH3:55])=[O:56].[O-:57][C:58]([CH3:59])=[O:60].[Pd+2:52].[c:30]1([CH3:31])[cH:32][cH:33][cH:34][cH:35][c:36]1[P:37]([c:38]1[cH:39][cH:40][cH:41][cH:42][c:43]1[CH3:44])[c:45]1[cH:46][cH:47][cH:48][cH:49][c:50]1[CH3:51]>>[c:2]1([CH:23]=[CH:22][c:24]2[cH:25][cH:26][n:27][cH:28][cH:29]2)[cH:3][cH:4][cH:5][c:6]2[c:10]1[C:9](=[O:11])[N:8]([c:12]1[cH:13][cH:14][c:15]([C:18]([CH3:19])([CH3:20])[CH3:21])[cH:16][cH:17]1)[CH2:7]2

Participants

7

Reactant 6

HCID 175Acetate2×HCID 75024-VinylpyridineHCID 8471TriethylamineHCID 80271Tri-o-tolylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 690317107-Bromo-2-(4-t-butyl-phenyl)-2,3-dihydro-isoindol-1-one

Product 1

HCID 690310652-(4-t-Butylphenyl)-7-(2-pyridin-4-yl-vinyl)-2,3-dihydro-isoindol-1-one

Sources & evidence

ORD record
ord-168e0a4455a349f29a2d6d003e20a80c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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