Tetrahydrofuran → [6-Benzhydryl-5-[(2,5-dimethoxyphenyl)methylamino]-1-azabicyclo[2.2.2]octan-2-yl]methanol

HRID 698916Notes

Reaction equation

HRID 698916 reaction equation
[Al+3:2].[CH2:45]1[O:46][CH2:47][CH2:48][CH2:49]1.[CH3:7][N:8]([C:9](=[O:10])[CH:11]1[N:12]2[CH:13]([CH:31]([c:32]3[cH:33][cH:34][cH:35][cH:36][cH:37]3)[c:38]3[cH:39][cH:40][cH:41][cH:42][cH:43]3)[CH:14]([NH:19][CH2:20][c:21]3[c:22]([O:29][CH3:30])[cH:23][cH:24][c:25]([O:27][CH3:28])[cH:26]3)[CH:15]([CH2:16]1)[CH2:17][CH2:18]2)[CH3:44].[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3]>>[CH2:9]([OH:10])[CH:11]1[N:12]2[CH:13]([CH:31]([c:32]3[cH:33][cH:34][cH:35][cH:36][cH:37]3)[c:38]3[cH:39][cH:40][cH:41][cH:42][cH:43]3)[CH:14]([NH:19][CH2:20][c:21]3[c:22]([O:29][CH3:30])[cH:23][cH:24][c:25]([O:27][CH3:28])[cH:26]3)[CH:15]([CH2:16]1)[CH2:17][CH2:18]2

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 22097567N,N-dimethyl-5-(2.5-dimethoxybenzyl)amino-6-diphenylmethyl-1-azabicyclo[2.2.2]octane2-carboxamide

Product 1

HCID 54206646[6-Benzhydryl-5-[(2,5-dimethoxyphenyl)methylamino]-1-azabicyclo[2.2.2]octan-2-yl]methanol

Sources & evidence

ORD record
ord-f02e868b328046d7843b44936f63d343
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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