Tetrahydrofuran → Tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate

HRID 699040Notes

Reaction equation

HRID 699040 reaction equation
[O:1]=[C:2]([O:3][CH2:4][CH3:5])[N:6]=[N:7][C:8]([O:9][CH2:10][CH3:11])=[O:12].[O:50]1[CH2:51][CH2:52][CH2:53][CH2:54]1.[OH:13][CH2:14][CH2:15][C:16]1([CH2:29][OH:30])[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]1.[c:31]1([P:32]([c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[cH:45][cH:46][cH:47][cH:48][cH:49]1>>[CH2:14]1[CH2:15][C:16]2([CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]2)[CH2:29][O:30]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 21955304tert-Butyl 4-(2-hydroxyethyl)-4-(hydroxymethyl)piperidine-1-carboxylate

Product 1

HCID 21955227Tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate

Sources & evidence

ORD record
ord-80d94164b08541b5adde80379a954fae
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…