Ammonium → Tert-butyl 4-ethynyl-4-hydroxypiperidine-1-carboxylate

HRID 699170Notes

Reaction equation

HRID 699170 reaction equation
[C:2](#[CH:3])[Mg+:4].[C:5](=[O:6])([O:7][C:8]([CH3:9])([CH3:10])[CH3:11])[N:12]1[CH2:13][CH2:14][C:15](=[O:18])[CH2:16][CH2:17]1.[CH2:21]1[O:22][CH2:23][CH2:24][CH2:25]1.[Cl-:19].[Cl-:1].[NH4+:20]>>[C:2](#[CH:3])[C:15]1([OH:18])[CH2:14][CH2:13][N:12]([C:5](=[O:6])[O:7][C:8]([CH3:9])([CH3:10])[CH3:11])[CH2:17][CH2:16]1

Participants

6

Reactant 5

HCID 223AmmoniumHCID 312Chloride2×HCID 8028TetrahydrofuranHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 178462448HCID 178462448, compound

Product 1

HCID 18366117Tert-butyl 4-ethynyl-4-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-2c2b30142e1e475d95549008dbff8acc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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